ORLANDO, Florida - A new report from Innerbody Research, utilizing the latest CDC STI Surveillance Statistics, reveals that several Florida cities are among the top 100 U.S. metropolitan areas with the highest sexually transmitted infection (STI) rates in 2025. The study, now in its eighth year, shows both concerning trends and slight improvements in the Sunshine State as the nation grapples with an ongoing STI epidemic. The U.S. South — a region that is home to roughly 39% of the population — accounts for over 60% of the top 25 metropolitan areas with the highest STI rates in this year's study. But, believe it or not, that's actually a slight improvement over last year's study. The number of Floridian cities in the top 100 has slightly increased, though Miami has improved relative to other cities, ranking 19th now instead of its previous 16th. Fort Lauderdale is no longer in the top 100. A staggering 48% of the total cases of chlamydia, gonorrhea, and primary and secondary syphilis occurred among young people ages 15-24, which could explain why Florida cities with younger populations have higher STI rates than those with older populations. Florida Cities in the Top 100 U.S. Cities with the Highest STI Rates 19. Miami, FL STI Cases / 100K Population: 1,192 HIV Cases: 1,095 Chlamydia Cases: 14,240 Gonorrhea Cases: 6,402 Syphilis Cases: 746 Notes: Improved from 16th in the previous year to 19th in 2025. 25. Tampa, FL STI Cases / 100K Population: 1,168 HIV Cases: 501 Chlamydia Cases: 14,969 Gonorrhea Cases: 6,349 Syphilis Cases: 876 31. Tallahassee, FL STI Cases / 100K Population: 1,081 HIV Cases: 90 Chlamydia Cases: 3,818 Gonorrhea Cases: 1,787 Syphilis Cases: 152 45. Jacksonville, FL STI Cases / 100K Population: 919 HIV Cases: 321 Chlamydia Cases: 9,634 Gonorrhea Cases: 5,124 Syphilis Cases: 405 65. Orlando, FL STI Cases / 100K Population: 786 HIV Cases: 592 Chlamydia Cases: 15,053 Gonorrhea Cases: 5,927 Syphilis Cases: 563 71. Pensacola, FL STI Cases / 100K Population: 756 HIV Cases: 72 Chlamydia Cases: 2,596 Gonorrhea Cases: 1,238 Syphilis Cases: 101 77. Daytona Beach, FL STI Cases / 100K Population: 728 HIV Cases: 145 Chlamydia Cases: 2,325 Gonorrhea Cases: 994 Syphilis Cases: 189 89. West Palm Beach, FL STI Cases / 100K Population: 599 HIV Cases: 294 Chlamydia Cases: 6,607 Gonorrhea Cases: 2,087 Syphilis Cases: 202 98. Naples, FL STI Cases / 100K Population: 379 HIV Cases: 60 Chlamydia Cases: 1,168 Gonorrhea Cases: 268 Syphilis Cases: 38