Florida Cities With The Most STDs In 2025

ORLANDO, Florida – A new report from Innerbody Research, utilizing the latest CDC STI Surveillance Statistics, reveals that several Florida cities are among the top 100 U.S. metropolitan areas with the highest sexually transmitted infection (STI) rates in 2025.

The study, now in its eighth year, shows both concerning trends and slight improvements in the Sunshine State as the nation grapples with an ongoing STI epidemic.

The U.S. South — a region that is home to roughly 39% of the population — accounts for over 60% of the top 25 metropolitan areas with the highest STI rates in this year’s study. But, believe it or not, that’s actually a slight improvement over last year’s study.

The number of Floridian cities in the top 100 has slightly increased, though Miami has improved relative to other cities, ranking 19th now instead of its previous 16th. Fort Lauderdale is no longer in the top 100.

A staggering 48% of the total cases of chlamydia, gonorrhea, and primary and secondary syphilis occurred among young people ages 15-24, which could explain why Florida cities with younger populations have higher STI rates than those with older populations.

Florida Cities in the Top 100 U.S. Cities with the Highest STI Rates

19. Miami, FL

• STI Cases / 100K Population: 1,192
• HIV Cases: 1,095
• Chlamydia Cases: 14,240
• Gonorrhea Cases: 6,402
• Syphilis Cases: 746
• Notes: Improved from 16th in the previous year to 19th in 2025.

25. Tampa, FL

• STI Cases / 100K Population: 1,168
• HIV Cases: 501
• Chlamydia Cases: 14,969
• Gonorrhea Cases: 6,349
• Syphilis Cases: 876

31. Tallahassee, FL

• STI Cases / 100K Population: 1,081
• HIV Cases: 90
• Chlamydia Cases: 3,818
• Gonorrhea Cases: 1,787
• Syphilis Cases: 152

45. Jacksonville, FL

• STI Cases / 100K Population: 919
• HIV Cases: 321
• Chlamydia Cases: 9,634
• Gonorrhea Cases: 5,124
• Syphilis Cases: 405

65. Orlando, FL

• STI Cases / 100K Population: 786
• HIV Cases: 592
• Chlamydia Cases: 15,053
• Gonorrhea Cases: 5,927
• Syphilis Cases: 563

71. Pensacola, FL

• STI Cases / 100K Population: 756
• HIV Cases: 72
• Chlamydia Cases: 2,596
• Gonorrhea Cases: 1,238
• Syphilis Cases: 101

77. Daytona Beach, FL

• STI Cases / 100K Population: 728
• HIV Cases: 145
• Chlamydia Cases: 2,325
• Gonorrhea Cases: 994
• Syphilis Cases: 189

89. West Palm Beach, FL

• STI Cases / 100K Population: 599
• HIV Cases: 294
• Chlamydia Cases: 6,607
• Gonorrhea Cases: 2,087
• Syphilis Cases: 202

98. Naples, FL

• STI Cases / 100K Population: 379
• HIV Cases: 60
• Chlamydia Cases: 1,168
• Gonorrhea Cases: 268
• Syphilis Cases: 38